Now, Ziyi can focus all her attentions on exciting experiments!
A great start with Mif2/CENP-C.
It took a while, but the Mif2 work by Dr. Hinshaw and my team is finally published. There is no question that Mif2 plays a key role in kinetochore assembly and we are starting to learn more about it.
Congratulations to Vivian
For being awarded the first Pfizer Oncology-Cell Signaling SD Graduate Fellowship, this is well deserved. We greatly appreciate Pfizer for its strong and generous support of basic science as the engine to drive impactful medical advances.
An amazing discovery!
For years, it has been unclear how genetic defects in the SUMO pathway may cause enormous chromosomal translocations, and this question has captured our attention. Our latest work provided the first clue, suggesting that SUMO modification of MCM controls its origin-bound levels. This finding is both surprising and exciting, and it provided an elegant explanation for the cause of chromosomal translocations - reduced MCM loading at DNA replication origins may cause incomplete DNA replication, leading to broken and un-replicated DNA, the precursor of chromosomal translocations.
The next step for three of our talented students.
Congratulations to Alex, Qian and Vivian, future Ph.D. candidates. They are ready for the hard work and fun in the graduate school.
An exciting new discovery!
With our collaborator Stephen, a new insight into how the inner kinetochore assembly is controlled!
See: https://www.biorxiv.org/content/10.1101/2021.11.04.467375v1.full.pdf
Congratulations to Vivian
for winning a poster prize at the 2021 SoCal Genome Stability Symposium!
A warm welcome to Anthony and Estefania!
Enjoy the journey of research
Congratulations to Qian!
for winning the prestigious UCSD Summer Research Fellowship and a chance to do great work.
Congratulations to Ray, Alex, Annie, Yang and Ben!
Our latest study clarifies how Mms21 activity in the cell is controlled through an adaptor Esc2, which played an early role in implicating the function of protein sumoylation in preventing genome rearrangements!
See: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247132