Enjoy the journey of research
Congratulations to Qian!
for winning the prestigious UCSD Summer Research Fellowship and a chance to do great work.
Congratulations to Ray, Alex, Annie, Yang and Ben!
Our latest study clarifies how Mms21 activity in the cell is controlled through an adaptor Esc2, which played an early role in implicating the function of protein sumoylation in preventing genome rearrangements!
See: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247132
2021 starts out with a new mechanism defined!
A fun collaboration with an outstanding scientist, Stephen Hinshaw: https://pubmed.ncbi.nlm.nih.gov/34081091/
The awesome power of collaboration and teamwork with the same goal to understand nature. This is just the beginning!
Congratulations to Ben
Ben received an A-plus for his thesis defense, according to one of the committee member. A job well done! We will beat Covid-19 next!
A direct link between the kinetochore and SUMO protease identified!
Congratulations to Ray, Yun, Yusheng, Julian and Claudio for a study that elucidates how the SUMO protease Ulp2 targets the kinetochore and shows how defect in this process leads to chromosome segregation errors.
Congratulations to Julian Yuan
Julian has successfully defended his masters degree, a job well-done. Best wishes!
New mechanism discovered! Congratulations to Claudio, Ray, Chris and Julian.
A basic feature of the SUMO protease Ulp2 has been found to play an unexpected and crucial role in regulating its substrate specificity, thanks to the ingenious and elegant design of nature! We are just witnesses, if we stop assuming!
Another exciting paper published!
In a wonderful collaboration with the Kolodner lab, Jason and Alex's paper describes the genetic basis of the genomic instability defect of cells lacking Mms21 SUMO E3 ligase, which points to an important role of SUMO in regulating DNA replication.
Congratulation to Ray
Ray has been selected as a postdoc trainee by the Growth Regulation and Oncogenesis Training Grant (NIH/NCI T32 CA009523). Of course, Ray will be using yeast as a model organism to understand the molecular basis of cancer, as the universality of fundamental mechanism has been well documented, in case you are wondering!