Vivian's first leading author paper.

Congratulations to Vivian for her first paper as a leading author and graduate student, see: https://www.biorxiv.org/content/10.1101/2024.07.26.605382v1.

Although untargeted MS has been used for decades as a discovery tool, there is a pressing need for accurate and robust quantification of cellular proteins. The new CASA technology that Vivian developed addresses a long standing bottleneck in protein quantification and opens the door to the the use of targeted MS for protein analysis in cell biology.

An amazing discovery!

For years, it has been unclear how genetic defects in the SUMO pathway may cause enormous chromosomal translocations, and this question has captured our attention. Our latest work provided the first clue, suggesting that SUMO modification of MCM controls its origin-bound levels. This finding is both surprising and exciting, and it provided an elegant explanation for the cause of chromosomal translocations - reduced MCM loading at DNA replication origins may cause incomplete DNA replication, leading to broken and un-replicated DNA, the precursor of chromosomal translocations.