Huilin Zhou Lab

2024

Cai J, Quan Y, Zhang CY, Wang Z, Hinshaw SM, Zhou H, Suhandynata RT, Concatemer Assisted Stoichiometry Analysis (CASA): targeted mass spectrometry for protein quantification. https://www.biorxiv.org/content/10.1101/2024.07.26.605382v1

Ng HY, Adly AN, Whelpley DH, Suhandynata RT, Zhou H, Morgan DO. Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing. BioRxiv [Preprint]. 2024 Feb 29:2024.02.28.582599.

Chambers LR, Ye Q, Cai J, Gong M, Ledvina HE, Zhou H, Whiteley AT, Suhandynata RT, Corbett KD. Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems. BioRxiv [Preprint]. 2023 Sep 26:2023.09.26.559546.

2023

Deng S, Cai J, Harrison SC, Zhou H, Hinshaw SM. Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex. EMBO Rep. 2023 Dec 6;24(12):e57702.

Hinshaw SM, Quan Y, Cai J, Zhou AL, Zhou H. Multi-site phosphorylation of yeast Mif2/CENP-C promotes inner kinetochore assembly. Curr Biol. 2023 Feb 27:1-9. PMID: 36736323

Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT. An E1-E2 fusion protein primes antiviral immune signalling in bacteria. Nature. 2023 Feb 8. doi: 10.1038/s41586-022-05647-4.

2022

Yun Quan, Qian-yi Zhang, Ann L. Zhou, Yuhao Wang, Jiaxi Cai, Yong-qi Gao, and Huilin Zhou. Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM. PLoS Genet. 2022 Jun 13;18(6):e1010275.

Li FL, Wu Z, Gao YQ, Bowling FZ, Franklin JM, Hu C, Suhandynata RT, Frohman MA, Airola MV, Zhou H, Guan KL. Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB. EMBO J. 2022 Sep 1;41(17):e110698.

Deep A, Gu Y, Gao YQ, Ego KM, Herzik MA Jr, Zhou H, Corbett KD. The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA. Mol Cell. 2022 Nov. 3; 82, 1-15.

2021

Stephen M. Hinshaw*, Yun Quan , Jiaxi Cai , Ann L. Zhou , and Huilin Zhou*. Multi-site phosphorylation of yeast Mif2/CENP-C promotes inner kinetochore assembly. https://www.biorxiv.org/content/10.1101/2021.11.04.467375v1

Serbyn N, Bagdiul I, Noireterre A, Michel AH, Suhandynata RT, Zhou H, Kornmann B, Stutz F. SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways. Cell Rep. 2021 Nov 23;37(8):110034.

Quan Y*, Hinshaw SM*, Wang PC, Harrison SC, Zhou H. Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore. J Cell Biol. 2021 Aug 2;220(8):e202012149. *Joint first authors.

Suhandynata RT, Gao YQ, Zhou AL, Yang Y, Wang PC, Zhou H. Shared and distinct roles of Esc2 and Mms21 in suppressing genome rearrangements and regulating intracellular sumoylation. PLoS One. 2021 Feb 18;16(2):e0247132.

2019

*Suhandynata RT, *Quan Y, Yang Y, Yuan W-T, Albuquerque CP and Zhou H. Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation. PLoS Genet. 2019 Nov 20;15(11):e1008477. *Joint first authors.

Ma J, et al. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 Mar 18;35(3):504-518.

Ho WY, Tai YK, Chang JC, Liang J, Tyan SH, Chen S, Guan JL, Zhou H, Shen HM, Koo E, Ling SC. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. 2019 Jan 23:1-16.

2018

*Albuquerque, CP, *Suhandynata, RT, Carlson, CR, Yuan, W-T and Zhou, H. Binding to Small Ubiquitin-like MOdifier and the nucleolar protein Csm1 regulates substrate specificity of the Ulp2 protease. J. Biol. Chem. 2018 Aug 3;293(31):12105-12119. *Joint first authors.

*Liang J, *Li BZ, Tan AP, #Kolodner RD, #Putnam CD, #Zhou H. SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements. PLoS Genet. 2018 Mar 5;14(3):e1007250. *Joint first authors. #Corresponding authors.

Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B. Identification of H3K4me1-associated proteins at mammalian enhancers. Nat Genet. 2018 Jan;50(1):73-82.

2017

*Liang, J., *Singh, N., Carlson C.R., Albuquerque, C.P., #Corbett, K.D., and #Zhou, H. (2017) Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes Dev. 2017 Apr 15;31(8):802-815. *Joint first authors. #Corresponding authors.

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, et al. (2017) mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell 67: 128–138.e7.

2016

*Albuquerque, C. P., *Liang, J., Gaut, N. J., and Zhou, H. (2016) Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements. J. Biol. Chem. 291, 8825–8835. *Joint first authors.

Suhandynata RT, Wan L, Zhou H, Hollingsworth NM (2016) Identification of Putative Mek1 Substrates during Meiosis in Saccharomyces cerevisiae Using Quantitative Phosphoproteomics. PLoS ONE 11: e0155931

2015

Albuquerque, C. P., Yeung, E., Ma, S., Fu, T., Corbett, K. D., and Zhou, H. (2015) A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. PLoS ONE. 10, e0143810.

Liang, J., Suhandynata, R. T., and Zhou, H. (2015) Phosphorylation of Sae2 Mediates Forkhead-associated (FHA) Domain-specific Interaction and Regulates Its DNA Repair Function. J. Biol. Chem. 290, 10751–10763.

Chen X, Suhandynata RT, Sandhu R, Rockmill B, Mohibullah N, Niu H, Liang J, Lo H-C, Miller DE, Zhou H, et al. (2015) Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol 13: e1002329.

Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, et al. (2015) Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. Neuron 86: 218–232.

Sun S, Ling S-C, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, et al. (2015) ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun 6: 6171.

2014

Suhandynata R, Liang J, Albuquerque CP, Zhou H, Hollingsworth NM (2014) A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture. G3 (Bethesda) 4: 2125–2135.

Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, et al. (2014) Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell 54: 378–391.

Farber-Katz SE, Dippold HC, Buschman MD, Peterman MC, Xing M, Noakes CJ, Tat J, Ng MM, Rahajeng J, Cowan DM, et al. (2014) DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. Cell 156: 413–427.

2013

Albuquerque, C. P., Wang, G., Lee, N. S., Kolodner, R. D., Putnam, C. D., and Zhou, H. (2013) Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements. PLoS Genet. 9, e1003670.

For earlier publications of Dr. Huilin Zhou: 

https://www.ncbi.nlm.nih.gov/myncbi/huilin.zhou.2/bibliography/public/

https://www.ncbi.nlm.nih.gov/myncbi/16sVjuXWCL05A/bibliography/public/